A recent study coming out of Penn State University is showing more positive results for the opiod antagonist Naltrexone. They studied 40 people who had active Crohn’s Disease and gave them a daily, orally administered, 4.5mg dose of Naltrexone or a placebo. Eighty percent of those treated with Naltrexone stated that they had improvement in their symptoms, 78% had confirmed benefit via endoscopy & 33% went into remission. Naltrexone had a huge lead against placebo, for example while 33% went into remission on Naltrexone, only 8% went into remission while taking the placebo. Overall it looks like Naltrexone may be of great help to those with Crohn’s Disease. Hopefully the positive results will continue as more studies are done.
For those with Irritable Bowel Syndrome, Naltrexone might be of use as well. There is another opioid based antagonist that’s being studied called Mu-Delta. It’s somewhat different than Naltrexone & the manufacturer is focusing on Irritable Bowel Syndrome specifically.