Canadian Researchers from the University of Toronto have narrowed down a key protein which may be partially to blame for triggering Crohn’s Disease.
The proteins in question are known as “nucleotide-binding oligomerization domain proteins” or NOD for short. The study looked specifically at the NOD2 gene which acts as a sort of “bacterial sensor” for the gut. It helps the immune system respond to threats by sending out signaling molecules(cytokines) which trigger an inflammatory response. The cytokines seen in this study are Interleukin(IL) 17 & IL-22. Interleukin 23 has also been linked to Crohn’s Disease. The research suggests that the NOD2 gene miscommunicates with IL-17 & IL-22 impeding the bodies ability to fight off bacterial infection. Continue reading “Immune System Proteins Key In Crohn’s Disease” »