Coronado Biosciences is developing a helminthic therapy treatment for Inflammatory Bowel Diseases such as Crohn’s Disease & Ulcerative Colitis that may open the therapy up to mainstream medicine.

Helminthic therapy is the treatment of autoimmune diseases or disorders via parasitic organisms, usually worms of some sort. Why helminthic therapy works rests on the hygiene hypothesis, which suggests that modern hygiene habits at an early age may be reducing the ability for our immune system to develop initially & later regulate itself. The idea is that without early exposure to certain pathogens, the immune system becomes reliant on allergic and/or inflammatory responses to common pathogens or irritants. Continue reading “Coronado Biosciences Developing Helminthic Therapy For Crohn’s Disease” »

Advanced techniques in stem cell therapy may lead to new treatment options for those with Inflammatory Bowel Diseases.

MultiStem is a stem cell treatment therapy currently in development by Athersys in partnership with Pfzier. Athersys is currently targeting MultiStem as a treatment for a variety of illnesses such as Inflammatory Bowel Disease but also things like recovery from stroke, heart problems & transplant rejection. Multistem starts by harvesting stem cells from the bone marrow of a donor. Due to the technique that Athersys uses the donor does not have to be a tissue match for the recipient like in some other stem cell treatments. Supposedly it is also easy to mass produce MultiStem as a single donor can produce hundreds of thousands or even millions of doses. Continue reading “Novel Stem Cell Treatments For Inflammatory Bowel Disease” »

Canadian Researchers from the University of Toronto have narrowed down a key protein which may be partially to blame for triggering Crohn’s Disease.

The proteins in question are known as “nucleotide-binding oligomerization domain proteins” or NOD for short. The study looked specifically at the NOD2 gene which acts as a sort of “bacterial sensor” for the gut. It helps the immune system respond to threats by sending out signaling molecules(cytokines) which trigger an inflammatory response. The cytokines  seen in this study are Interleukin(IL) 17 & IL-22. Interleukin 23 has also been linked to Crohn’s Disease. The research suggests that the NOD2 gene miscommunicates with IL-17 & IL-22 impeding the bodies ability to fight off bacterial infection. Continue reading “Immune System Proteins Key In Crohn’s Disease” »

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