Lexicon Pharmaceuticals recently announced their new drug LX1033 passed Phase I drug safety trials allowing it to move forward into Phase II testing.
Lexicon Pharmaceuticals’ LX1033 is a Irritable Bowel Syndrome drug meant for those with diarrhea predominant Irritable Bowel Syndrome symptoms or mixed symptoms that include diarrhea. LX1033 works by targeting the hydroxylase enzyme which is also known as TPH. TPH is essential for the production of serotonin within the body & it comes in two forms TPH1 & TPH2. TPH1 lives mainly in the digestive system, while TPH2 lives in the nervous system & the brain. LX1033 specifically targets TPH1 only & leaves TPH2 alone to avoid nervous system or psychoactive effects. Serotonin levels do seem to play a role in Irritable Bowel Syndrome, but how much is not fully understood. Continue reading “Lexicon Pharmaceuticals Drug LX1033 For Irritable Bowel Syndrome” »
Hydrogenotrophic microbes which convert hydrogen into other substances may play a key role in the development of diseases like Colon Cancer or Inflammatory Bowel Disease.
Research lead by Professor Rex Gaskin & Dr. Eugene Greenberg at the University of Illinois is looking to map Hydrogenotrophic(hydrogen consuming) microbes that while making up a small portion of the microbial ecosystem might play a big part in the development of diseases such as Colon Cancer or Inflammatory Bowel Diseases such as Crohn’s Disease or Ulcerative Colitis. Continue reading “Hydrogen Eating Microbes Play Important Role In Digestive System” »
On July 15th the US Department of Veterans Affairs announced that disability regulations will be changing regarding how the Department of Veterans Affairs views Functional Gastrointestinal Disorders(FGIDs/FGIMDs) such as Irritable Bowel Syndrome.
The new regulations will now list FGIDs as being a “presumed” result of military service during operations within Southeast Asia during the Persian Gulf War that occurred in the early 1990s. This essentially means that a veteran making a disability claim should have an easier task of claiming that their Irritable Bowel Syndrome or Functional Dyspepsia(chronic indigestion) was a result of their service, even if symptoms developed after they had left the military. In the past a veteran had to prove that their symptoms were apparent while they were actively serving during the Gulf War. This made it complicated for many veterans who developed severe gastrointestinal disorders after their tours of duty ended. Continue reading “US Veterans Affairs Disability Regulations More Accepting of IBS” »
After relatively successful Phase III trials Ironwood Pharmaceuticals’ has applied for final FDA approval of their flagship drug, Linaclotide, which is for the treatment of constipation & pain related Irritable Bowel Syndrome symptoms.
Continue reading “Ironwood Pharmaceuticals’ Linaclotide IBS Drug Looking For Final FDA Approval” »
Those trying to improve their health may actually be making it worse or even risking severe injury by taking colon cleansing products which are often costly & have dubious benefit.
A few months ago I wrote about my negative thoughts on colon cleansing products & how I felt they weren’t healthy, safe or cost effective treatment for digestive system problems. Of all the bogus health products out there colon cleansing is probably at the top of the list for deceiving people about it’s potential benefits. Continue reading “Colon Cleansing Offers Little Benefit & Dangerous For Some” »
Health Canada is strengthening the required side effect warnings on prescriptions of Reglan so that they include more information regarding the likelihood of someone developing debilitating Tardive dyskinesia.
Reglan is the brand name of the drug Metoclopramide which has been used for decades to as an anti-emetic & prokinetic drug. Health Canada is the department which sets health policy within Canada. Health Canada has come out with stronger warnings regarding the major side effect of Tardive dyskinesia. The new warnings will now be required for all prescriptions of Reglan. Continue reading “Reglan Tardive Dyskinesia Side Effect Warnings Boosted In Canada” »
About a month ago I contacted my local congressman, David Wu, asking for his support on “H.R. 2239 – Functional GI and Motility Disorders Research Enhancement Act of 2011“. He recently sent a response back outlining his views on the pending legislation.
Just to recap here is the original letter I sent to David Wu via his website.
I would just like to bring your attention to the house bill HR 2239 “Functional Gastrointestinal and Motility Disorders Research Enhancement Act of 2011”.
I have personally suffered from Irritable Bowel Syndrome for 14 years and went through an acute case of Gastroparesis for 3 months. Both of these diseases have had a profound & lasting affect on my life. Motility related digestive illnesses greatly affect a person’s quality of life & they greatly impact a person’s social, educational & career endeavors. With almost 20% of Americans facing some form of digestive motility disorder, it’s a shame that there isn’t more funding given to researching these diseases.
I ask that you please become a cosponsor of H.R. 2239 by contacting Amy Bos in the office of Congressman James Sensenbrenner, Jr.
Gabriel Hedges Continue reading “David Wu Responds To My H.R. 2239 Inquiry” »
A recent minor spat between the University of Iowa & the University of Melbourne brings awareness to the roles that prunes, sorbitol & FODMAPs play in Irritable Bowel Syndrome.
Prunes were the topic of discussion in a recent debate over their effectiveness in treating Irritable Bowel Syndrome constipation. The debate started over a bit of research done by the University of Iowa’s Department of Gastroenterology which suggested that prunes were possibly a more effective treatment option than psyllium husks for those with Irritable Bowel Syndrome constipation. Continue reading “Irritable Bowel Syndrome & The Great Prune Debate” »
The American Idol “Top 6” finalist, Casey Abrams, looks to highlight inspiring stories of those who have pushed beyond the limitations Inflammatory Bowel Disease imposes on their life.
Casey Abrams’ battle with Ulcerative Colitis came to light earlier this spring while competing on American Idol. Despite trying to put on a strong face & not bring attention to himself due to his illness, he eventually became so ill that he had to be hospitalized & receive blood transfusions. Since the news of his health problems became known, he has received an outpouring of support from his fans & those who have Inflammatory Bowel Diseases like Crohn’s Disease & Ulcerative Colitis. Mr. Abrams recently spoke with FOX’s Beth Galvin about the struggles he faced during American Idol & beyond. Continue reading “Singer Casey Abrams Raising Awareness With IBD Icons Project” »
Coronado Biosciences is developing a helminthic therapy treatment for Inflammatory Bowel Diseases such as Crohn’s Disease & Ulcerative Colitis that may open the therapy up to mainstream medicine.
Helminthic therapy is the treatment of autoimmune diseases or disorders via parasitic organisms, usually worms of some sort. Why helminthic therapy works rests on the hygiene hypothesis, which suggests that modern hygiene habits at an early age may be reducing the ability for our immune system to develop initially & later regulate itself. The idea is that without early exposure to certain pathogens, the immune system becomes reliant on allergic and/or inflammatory responses to common pathogens or irritants. Continue reading “Coronado Biosciences Developing Helminthic Therapy For Crohn’s Disease” »